Process-level Target PredictionProcess-level target predictions are the Gene Ontology terms which are enriched among genes which have a similar genetic interaction profile to the chemical genetic interaction profile. For example, Benomyl has an enrichment for tubulin complex assembly because the chemical genetic interaction profile for Benomyl is similar to the genetic interaction profiles for GIM3, GIM4, GIM5, YKE2, CIN1, CIN2, and PAC10, which are all annotated to tubulin complex assembly.
Empirical p-values and z-scores are calculated by calculating a mean gene target prediction score for genes within a GO term and comparing it to a null distribution. Two false discovery rates were calculated based on comparing the predicted z-score to control compound chemical genomic profiles or randomized resampled chemical genomic profiles.
Predictions in white are considered high confidence (FDR<25). Predictions in gray are outside of the high confidence threshold.
| Chemical Name |
GO Name |
GO ID |
p-value |
z-score |
FDR_DMSO |
FDR_RAND |
Gene-level Target Prediction Gene-level target predictions are the genes which have similar genetic interaction profiles to the compound of interest. Gene-level target prediction dotcosine scores are calculated by computing a cosine score between the chemical genetic interaction profile and a normalized genetic interaction profile. For example, the chemical genetic interaction profile of Benomyl is similar to its supposed protein target's genetic interaction profile, TUB3.
Compounds in white have at least one high confidence (FDR<25) process-level target prediction. Compounds in gray do not have any high confidence predictions.
| Chemical Name |
Gene Common Name |
Gene ORF Name |
dotcosine |
Chemical Genetic Profile These are the chemical genetic interaction sensitivities (-) and resistances (+). The chemical genetic interaction scores are a z-score which represents the standardized deviation of each strain in the condition profile with respect to its counterpart strain in the reference DMSO profiles.
Compounds in white have at least one high confidence (FDR<25) process-level target prediction. Compounds in gray do not have any high confidence predictions.
| Chemical Name |
Gene Common Name |
Gene ORF Name |
Score |
Chemical Similarity The chemical similarity or structural similarity is calculated using the All-Shortest Path (ASP) structure descriptor (depth 8) along with the Braun-Blanquest similarity coefficient.
Compounds in white means chemical 2 have at least one high confidence (FDR<25) process-level target prediction. Compounds in gray means chemical 2 does not have any high confidence predictions.
| Chemical 1 |
Chemical 2 |
Score |
Profile SimilarityProfile similarity or functional similarity is measured using a pearson correlation on the chemical genetic interaction profiles.
Compounds in white means chemical 2 have at least one high confidence (FDR<25) process-level target prediction. Compounds in gray means chemical 2 does not have any high confidence predictions.
| Chemical 1 |
Chemical 2 |
Score |
